The first question you need to ask yourself is, why do I want to do this? Understanding your motivation for tackling a subject helps to define what sort of story you wish to write. Personally, tackling taboo subjects is one of main motivators for writing. I like the idea of bringing them to the fore so people can talk about them.
Sometimes I get the feeling that people want to talk about a particular issue but they wait for others to raise it first. I have had long and deep discussions about depression, for example, and I have found them informative and rewarding. Writing a story on the subject is like giving people an ice breaker.
I’ll admit, putting these subjects out there in story form is scary. There are those who are not willing to discuss matters and would prefer them to remain hidden. For too long though, we have oppressed those who cannot and possibly will not speak loudly enough. I think it is about time we gave them a chance to be heard.